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Analytical to Semi-Preparative HPLC Purification


Integrate the versatility of Empower Software with the simplicity of Waters chromatography solutions for a flexible purification solution that will meet your laboratory's needs.


Waters' analytical to semi-preparative purification solutions are suitable for when you only have a limited number of samples to purify and don't need the advanced features of a full preparative system. These systems can sit on the end of the benchtop waiting for your chemists to use on-demand. These systems are optimal for when you want to purify micrograms to milligrams of your compounds.


Waters offers a full line of solvent delivery systems capable of delivering flow rates up to 300 mL/min.

Semi-Preparative to Preparative-Scale HPLC Purification


Preparative-scale chromatography plays a critical role in applications where compounds must be synthesized, identified, isolated, purified, characterized, screened, and tested. Waters AutoPurification Systems offer scalable prep configurations, whether you want the specificity of mass-directed purification or inclusiveness of a UV system.


The AutoPurification HPLC/MS System provides you with the flexibility of using high-throughput parallel runs for selective mass-directed fraction collection from hundreds of samples. With the AutoPurification HPLC System, run samples around the clock with unprecedented versatility and consistency.

  • Take the complexity out of purification with our versatile solutions that are capable of purifying micrograms to multigram quantities.

  • Automatically process hundreds of samples - or just a few.

  • Robust and reliable systems improve your ability to manage increasing workload demands, including unattended instrument operation.

  • Flexible configurations enable easy scale-up from analytical to preparative chromatography.

  • FractionLynx Application Manager automates the collection of detected fractions, tracks samples and fractions, and then presents the data in an easy-to-view format. The software can trigger collection using a variety of detector signals including UV/Visible, Evaporative Light Scattering (ELS), MS, and analog.

  • User-friendly console and software features help you manage solvents and samples, whether you do manual or automated injections.

  • Proprietary Optimum Bed Density (OBD) Column design offers the highest sample loading and unmatched column stability.

  • Easy-to-upgrade systems help you bring the latest technologies to your lab.

Semi Preparative to Preparative-Scale SFC Purification


Purification scientists around the globe are excited by the latest advancements in supercritical fluid chromatography, or SFC, that are now backed by the powerful support of Waters. Because SFC technology uses CO2 as its main solvent, it is a critically important solution for prep laboratories that want to be more green: Less solvent to buy; less to dispose of. And SFC means much less time and money spent on both.


  • Where eco-friendly is an important consideration to high-throughput purification capabilities

  • Fully automated UV - or mass-directed purification§ Reduced fraction drydown time increases throughput

  • Intelligent instrument control meets demanding fraction collection workflow needs with MassLynx Software's FractionLynx Application Manager


Prep 100q SFC System Waters Prep 100q SFC System is the only preparative scale, open-bed supercritical fluid chromatography (SFC) system specifically designed for seamless, mass-triggered purification.


Investigator SFC System For when you need to purify a large amount of single samples, but still do method development. The analytical/semi-prep Investigator SFC has the unique ability to isolate and collect less than 1 gram of a specific compound.


Optical Detectors for Purification and Modular LC Systems HPLC optical detectors provide additional analytical detail about your samples. When paired with their accessories, such as flow cells or nebulizers, you can obtain more information per run, fulfilling multiple detection strategy requirements.

Preparative-Scale SFC Purification


Waters' suite of bulk-scale SFC purification systems offer the optimal system for the amount of sample you need to purify. These systems easily allow you to purify a large amount of one sample.


Preparative Supercritical Fluid Chromatography 80q, 200q, and 350 are automated systems that feature co-solvent gradient, high-pressure separators for quantitative recovery of purified products, such as enantiomers, complex synthetic chemicals, and natural products. They are designed for chiral and achiral separations.


SFC 80/200/350 Preparative Systems Waters SFC 80, 200, and 350 Preparative systems for bulk-scale purification offer the optimal system for the amount of sample you need to purify. These systems easily allow you to purify a large amount of one sample.


2489 UV/Visible (UV/Vis) Detector for Purification and Modular LC Systems A versatile, dual-wavelength absorbance detector that offers simplicity for routine UV-based applications and high sensitivity for low-level impurity analysis.